From mild-to-moderate to severe asthma: Risk factors and patient profiles from the NORDSTAR cohort - PubMed

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Overall, 4.1% of patients with mild-to-moderate asthma progressed to severe asthma within five years after their first exacerbation.
Risk factors for progression included: age 40-49 years, exacerbations despite medium-dose inhaled corticosteroid use, high short-acting beta agonist use, ≥2 respiratory infections, and elevated blood eosinophil counts (≥0.6×10⁹/L).
Specific high-risk patient profiles, such as a 40-49-year-old with late-onset eosinophilic asthma on medium-dose ICS and recurrent infections, faced a 30.4% five-year risk of progression.
Early recognition of high-risk profiles may help, but further research is needed to determine if it can modify progression risk.

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