Beyond antibiotics: innovative and translational strategies to overcome antimicrobial resistance - PubMed
3 hours ago
- #antimicrobial resistance
- #beyond-antibiotic therapies
- #translational medicine
- The rapid rise of antimicrobial resistance necessitates therapeutic strategies beyond conventional antibiotics.
- This review synthesizes emerging beyond-antibiotic approaches, including antimicrobial peptides, bacteriophage therapy, CRISPR-based antimicrobials, nanotechnology, anti-virulence agents, host-directed immunotherapies, microbiome modulation, and drug-repurposing or combination therapies.
- It provides a comparative framework linking mechanisms of action, engineering innovations (e.g., peptidomimetics, engineered phages, nanoparticle carriers), and translational evidence across these strategies.
- Key barriers to clinical translation are identified: delivery efficiency, toxicity, ecological concerns, production challenges, cost, inconsistent clinical outcomes, and regulatory fragmentation.
- A translational roadmap is proposed to facilitate implementation, emphasizing standardized assays, physiologically relevant models, integrated diagnostics, and tailored regulatory frameworks.