An implantable mechano-electro cascade platform synchronizes neuro-muscle repair - PubMed
3 hours ago
- #neuromuscular repair
- #bioelectronic implant
- #nerve regeneration
- An implantable mechano-electro cascade platform called MEBIS enables synchronized neuromuscular repair.
- It uses mechanical massage to enhance muscle perfusion and a nanogenerator to convert motion into electrical signals that stimulate nerve regeneration.
- The system activates intracellular calcium and downstream pathways (HIF-1α/AMPK), accelerating Schwann cells, angiogenesis, and axonal growth.
- MEBIS overcomes limitations of conventional stimulators and has been validated in animal models (rat and porcine) without biocompatibility issues.
- The platform provides a scalable, feedback-controlled approach for precision repair and rehabilitation after peripheral nerve injury.