An integrated systemic approach to chronic primary pain from epigenome to brain: a narrative review - PubMed
3 hours ago
- #chronic pain
- #epigenetics
- #neuroinflammation
- Chronic primary pain involves epigenetic modifications affecting inflammation-related genes, neurotrophic factors, neurotransmitters, ion channels, and catecholamine-degrading enzymes.
- It is characterized by structural and functional central nervous system changes, neuroinflammation, and links to sensory hypersensitivity, stress intolerance, and sleep disturbances.
- An integrated systemic approach connects physiological dysfunctions (brain changes, neuroinflammation, immune alterations, genetic/epigenetic changes) with clinical features and human studies to bridge scientific gaps.