Microbial metabolites at the front line: Orchestrating gastrointestinal and systemic barrier immunity across the lifespan - PubMed
3 hours ago
- #microbial metabolites
- #barrier immunity
- #gut-skin axis
- Microbial metabolites are key mediators between gut microbiota and the host immune system at mucosal barriers.
- Short-chain fatty acids, tryptophan catabolites, and bile acid derivatives regulate epithelial integrity, immune tone, and tolerance.
- Dysregulation of these metabolites is linked to diseases like inflammatory bowel disease, asthma, and atopic dermatitis.
- The review explores the gut-lung and gut-skin axes and the role of metabolites in orchestrating barrier immunity.
- Early-life exposure to metabolites during critical developmental windows influences long-term immune health.