Biophysical modeling for accurate T cell specificity prediction of viral and tumor antigens - PubMed
2 hours ago
- #TCR specificity prediction
- #immunotherapy
- #biophysical modeling
- Developed a dual experimental and computational framework for predicting TCR antigen specificity in clinical samples.
- Integrated TCR sequences with structural TCR-pMHC data, including using sequence-based clustering and diverse templates to enhance accuracy.
- Applied the model to HLA-A*02-restricted epitopes for tumor and viral antigens, demonstrating robust predictions with limited training data and across patient samples.
- Proposed scalable strategy for TCR specificity prediction with applications in immunotherapy, vaccine design, and immune monitoring.