Associations of metabolic score for insulin resistance and new-onset stroke in middle-aged and older adults: a national cohort study - PubMed
4 hours ago
- #stroke risk
- #insulin resistance
- #METS-IR
- Study investigates link between cumulative METS-IR (cumMETS-IR) and METS-IR change patterns with new-onset stroke in middle-aged and older adults using data from CHARLS.
- Higher cumMETS-IR quartiles were associated with increased stroke incidence, with the highest quartile showing a 72% higher risk compared to the lowest.
- Four distinct METS-IR change patterns identified: low-stable, low-to-moderate stable, moderate-to-high stable, and high-decreasing, with the high-decreasing pattern linked to the highest stroke risk.
- Diastolic blood pressure (DBP) partially mediated the association between cumMETS-IR and stroke, accounting for 9.6% of the effect.
- Findings suggest that monitoring METS-IR over time could aid in comprehensive metabolic assessment and stroke risk evaluation.