Subtype Differences in Major Adverse Liver Outcomes and Cardiovascular Events and Mortality in Steatotic Liver Disease: A UK Biobank Analysis - PubMed
3 hours ago
- #cardiovascular risk
- #SLD subtypes
- #liver outcomes
- Study analyzed 244,760 UK Biobank participants to compare risks across SLD subtypes: MASLD (19.6%), MetALD (9.4%), and ALD (3.3%).
- Over median 13.5 years, incidence rates per 1,000 person-years were highest for ALD across all outcomes: MALO (5.80), MACE (19.36), and all-cause mortality (20.93).
- Adjusted hazard ratios showed ALD had significantly higher MALO risk vs. MASLD (HR 2.95) and higher risks of MACE and mortality compared to both MetALD and MASLD.
- MetALD had higher MALO risk than MASLD (HR 1.23) but similar risks for MACE and all-cause mortality, with no significant differences between MetALD and MASLD for cardiovascular or survival outcomes.
- Conclusions indicate ALD presents the greatest liver, cardiovascular, and mortality risks, while MASLD and MetALD share similar cardiovascular and survival profiles but differ in liver-related outcomes.