Exosomes in Glioma: Integrating Molecular Mechanisms with Diagnostic and Therapeutic Potential - PubMed
3 hours ago
- #Exosomes
- #Glioma
- #Tumor Microenvironment
- Exosomes are nanoscale extracellular vesicles that act as master regulators of intercellular communication, shaping the glioma tumor microenvironment and driving malignancy hallmarks like immune evasion and angiogenesis.
- They transport bioactive cargo (e.g., miRNAs, lncRNAs, proteins) to reprogram stromal, neuronal, and immune cells, creating a permissive niche for tumor progression.
- Recent advancements position exosomes in translational medicine with dual roles: as minimally invasive biomarkers for diagnosis and as engineered nanovectors for precision therapy in glioma.
- The review explores how exosomes contribute to glioma pathogenesis, including macrophage polarization, T-cell suppression, blood-brain barrier disruption, and chemoresistance.
- Innovative strategies are being developed to harness exosomes for drug delivery, immunotherapy, and nanotechnology-driven interventions, bridging discoveries with clinical applications for personalized glioma management.