Neonatal Lactic Acidosis Associated With Antiretroviral Exposure: A Case Report - PubMed
3 hours ago
- #lactic acidosis
- #neonatal care
- #antiretroviral therapy
- A 7-day-old boy born to an HIV-positive mother on antiretroviral prophylaxis (lamivudine, zidovudine, nevirapine) presented with persistent irritability and tachycardia.
- Laboratory evaluation revealed elevated and worsening serum lactate levels, indicating lactic acidosis.
- The antiretroviral regimen was modified to raltegravir and lamivudine, leading to metabolic improvement.
- This case highlights the importance of recognizing ART-related toxicity in neonates, even with subtle initial symptoms, to allow early treatment adjustment and monitoring.