Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons - PubMed
3 hours ago
- #Synaptogenesis
- #Schizophrenia
- #Neurodevelopment
- ZNF804A is a schizophrenia risk gene identified through large-scale genomic studies, associated with regulating gene expression and synaptic function.
- Using isogenic human induced pluripotent stem cells with reduced ZNF804A expression, cortical glutamatergic neurons showed increased excitatory synapse density despite modest gene expression changes.
- Proteomic analysis revealed higher levels of ribosomal and translational proteins in neurites of mutant neurons, leading to increased local protein synthesis efficiency.
- The study demonstrates that ZNF804A regulates excitatory synapse formation in developing human neurons by controlling local protein translation, linking it to schizophrenia pathogenesis.