A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - PubMed
2 hours ago
- #ribosomal E-site
- #antibiotic discovery
- #multidrug resistance
- A natural depsipeptide antibiotic, manikomycin, was discovered from Streptomyces rimosus.
- Manikomycin kills multidrug-resistant Enterobacteriaceae and avoids resistance from existing antibiotics.
- It binds the E-site of the bacterial ribosome, hindering tRNA translocation and protein synthesis.
- This represents a new antibacterial mechanism, targeting an underexplored ribosomal site.
- The discovery involved improved fractionation to find minor products in well-studied actinomycetes.