Neuron-tumor interplay in colorectal cancer: from mechanisms of onset and progression to targeted therapies - PubMed
2 days ago
- #Enteric Nervous System
- #Colorectal Cancer Therapy
- #Cancer Neuroscience
- Neuron-tumor interactions in colorectal cancer (CRC) involve the nervous system, particularly the enteric nervous system (ENS), influencing tumor initiation, progression, and metastasis.
- Neurotransmitters (e.g., norepinephrine, acetylcholine) and neurotrophic factors (e.g., NGF, BDNF) regulate CRC cell proliferation, invasion, and immune microenvironment remodeling.
- The brain-gut-microbiome axis affects tumor progression through metabolic reprogramming and neuroimmune crosstalk.
- Targeted therapies leveraging neuron-tumor interplay offer new perspectives for precise CRC interventions.