Natural variations in small RNA origin loci generate circuit diversity underlying temperature acclimation in Caenorhabditis elegans - PubMed
5 hours ago
- #small RNA
- #temperature acclimation
- #natural variation
- Natural genetic variations in small RNA origin loci lead to differences in temperature acclimation among Caenorhabditis elegans individuals.
- The gene smrn-1, part of a conserved nematode gene family, produces abundant small RNAs in embryos under the helicase ERI-6/7.
- smrn-1-derived small RNAs bind to Argonaute protein HRDE-1, regulating axonogenesis in O2-sensing BAG neurons through an axonogenesis regulator.
- BAG neuron signals influence temperature-sensing neurons, creating individual diversity in thermal responsiveness and acclimation.
- Gene polymorphisms in epigenetic regulators during evolution may generate adaptive neural circuits for temperature acclimation in nematodes.