Duration of antibiotic therapy for bacteremia in immune compromised hosts-a post hoc subgroup analysis of the BALANCE randomized clinical trial - PubMed
3 hours ago
- #immunocompromised hosts
- #antibiotic duration
- #bacteremia
- The BALANCE trial found 7 days of antibiotics non-inferior to 14 days for bacteremia, but effectiveness in immunocompromised patients was unclear.
- This post-hoc subgroup analysis focused on 1,037 immunocompromised patients, mainly with solid malignancies, leukemia/lymphoma, or on chemotherapy.
- 90-day mortality rates were 20.1% (7-day arm) and 23.7% (14-day arm) with no significant difference, suggesting 7-day therapy is sufficient for these patients.