MRI-defined tissue damage as predictors of the incidence and progression of knee osteoarthritis: A systematic review - PubMed
3 hours ago
- #Knee Osteoarthritis
- #Systematic Review
- #MRI Prediction
- MRI is increasingly used to predict knee osteoarthritis (KOA) incidence and progression, as shown in a systematic review of 99 studies.
- Strong predictors of KOA incidence include baseline bone marrow lesions (BMLs), specific bone shape patterns, meniscal tears, and synovitis.
- Predictors of KOA progression, characterized by increasing cartilage damage, include meniscal extrusion, synovitis, and BMLs.
- Baseline cartilage T2 signal abnormalities strongly predict future structural cartilage defects, indicating a pathway from compositional to structural deterioration.
- MRI-detected pathologies help stratify patients for disease-modifying osteoarthritis drug trials and associations may improve with advanced MRI models and AI.