CD4+ T cells impair tumor growth through IL-3 and TNF-dependent vascular damage - PubMed
3 hours ago
- #tumor immunity
- #vascular damage
- #immunotherapy
- CD4+ T cells inhibit tumor growth by damaging tumor blood vessels through IL-3 and TNF.
- These T cells form perivascular myeloid cell clusters, with macrophages producing TNF in response to IL-3 from T cells.
- TNF causes endothelial damage and blood supply disruption, leading to localized tumor cell death.
- This mechanism avoids direct tumor cell recognition, bypassing common inhibitory pathways in anti-tumor immunity.
- The findings suggest an alternative strategy for cancer immunotherapy beyond traditional direct tumor-killing approaches.