Prognostic factors and a novel scoring system for allogeneic hematopoietic stem cell transplantation in patients aged 70 years or older: a nationwide registry analysis in Japan - PubMed
4 hours ago
- #Hematopoietic stem cell transplantation
- #Prognostic scoring
- #Elderly patients
- Study analyzed 929 patients aged 70+ undergoing first allo-HSCT for hematologic malignancies in Japan (2000-2022).
- Median age was 71 years; the most common disease was acute myeloid leukemia.
- Overall 2-year survival rate was 34.2%.
- Adverse prognostic factors identified: age ≥75, ATL, lymphoma, high disease risk, HCT-CI ≥5, and PS ≥2.
- A novel hazard ratio-based scoring system stratified patients into four risk groups (0 to 5 points).
- 2-year OS rates: low-risk (0 points) 57.1%, intermediate-1 (1 point) 35.0%, intermediate-2 (2-3 points) 18.3%, high-risk (4-5 points) 2.5% (p<0.01).
- Scoring system aims to help select older patients most likely to benefit from allo-HSCT.