Association of hematopoietic mosaic loss of chromosome Y with dermatitis and eczema risk: an analysis in a large-scale prospective cohort study - PubMed
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- #sex differences
- #dermatitis and eczema
- #mosaic loss of chromosome Y
- Hematopoietic mosaic loss of chromosome Y (mLOY) is linked to increased risk of incident dermatitis and eczema (DE) in men, with high mLOY (>20%) showing the strongest association (adjusted HR 1.44).
- mLOY contributes to male susceptibility to DE; males without mLOY have similar risk as females, but low and high mLOY levels lead to progressively higher risks.
- Younger men with high mLOY exhibit DE risk comparable to older men without high mLOY, suggesting accelerated biological aging due to mLOY.
- The highest DE risk is seen in men with both high mLOY and a high polygenic risk score for DE (adjusted HR 1.85).
- Circulating metabolites, particularly lipoprotein-related traits, mediate the mLOY-DE association, indicating modifiable metabolic pathways for risk assessment in older men.