Public antibody clonotypes and deep learning identify SARS-CoV-2 and HIV broadly neutralizing antibodies in immune repertoires - PubMed
4 hours ago
- #Vaccine Development
- #Broadly Neutralizing Antibodies
- #AI in Immunology
- ClonoDeep is an AI platform that identifies broadly neutralizing antibodies (bnAbs) for pathogens like SARS-CoV-2 and HIV from immune repertoires without needing antigen-specific immunization.
- For SARS-CoV-2, ClonoDeep found 18 antibody candidates, with 83% being neutralizing, and 8 showing broad neutralization across variants.
- Key structural findings show somatic hypermutations at HCDR3 His107/Gly109 enhance binding affinity and neutralization breadth in SARS-CoV-2 antibodies.
- ClonoDeep also identified three previously unreported HIV bnAbs from non-HIV cohorts, suggesting rare bnAb-like precursors exist in general immune repertoires.
- This high-throughput computational approach aids in discovering neutralizing antibodies and guides vaccine design against diverse pathogens.