Macrophage EHD1 Promotes Inflammation and Stabilizes Sortilin to Accelerate Atherosclerosis - PubMed
7 hours ago
- #atherosclerosis
- #EHD1
- #macrophage inflammation
- Macrophage EHD1 expression increases with atherosclerosis progression in both mice and humans.
- Deletion of EHD1 reduces atherosclerotic lesion size and attenuates proinflammatory responses.
- EHD1 promotes endocytic recycling of TNFR2, activating NF-κB and increasing inflammatory cytokines.
- EHD1 interacts with retromer to stabilize sortilin, a known atherosclerosis risk factor.
- The study identifies EHD1 as a key regulator in macrophage inflammation and atherosclerosis, suggesting potential therapeutic targets.