FGF21 suppresses hepatocellular carcinoma by driving competitive cell-cell interactions - PubMed
3 hours ago
- #FGF21
- #hepatocellular carcinoma
- #cell competition
- FGF21 suppresses hepatocellular carcinoma (HCC) by driving tumor-suppressive cell competition in the liver.
- FGF21, secreted by oncogenic hepatocytes, causes directional migration of normal hepatocytes, mechanically eliminating oncogenic cells.
- NOS3-mediated S-nitrosylation of ASK1 at Cysteine 869 induces FGF21 expression and triggers cell competition.
- Modulating FGF21 levels affects HCC progression: depletion accelerates tumor development, while overexpression suppresses it.
- FGF21 is identified as a physiological driver of tumor suppression and a potential therapeutic target for early-stage HCC.