Brief Report: The Prognostic Impact of Common Molecular Alterations in Resected Lung Adenocarcinoma and Implications for the 10th Edition TNM Classification - PubMed
3 hours ago
- #lung adenocarcinoma
- #TNM staging
- #molecular prognosis
- EGFR mutations are linked to better overall survival in stage I lung adenocarcinoma.
- TP53 mutations and KRAS mutations are associated with worse overall survival in stage I patients.
- ALK fusions show improved overall survival in stage III-IV tumors, suggesting potential downstaging.
- Molecular alterations like TP53, KRAS, and ALK could refine the TNM staging system for lung cancer.
- Study findings may influence the 10th Edition TNM classification by integrating gene mutation data.