Repurposing Syrosingopine for Cancer Therapy: Lactate Trapping and ISR Sensitization as Metabolic Vulnerabilities - PubMed
3 hours ago
- #Metabolic Therapy
- #Cancer Metabolism
- #Drug Repurposing
- Syrosingopine repurposed as a dual lactate transporter (MCT1/MCT4) inhibitor to exploit the Warburg effect in cancer.
- Mechanism involves lactate trapping, NAD+ depletion, and bioenergetic stress, enhancing synthetic lethality with mitochondrial inhibitors.
- Advanced delivery systems improve intratumoral drug accumulation and modulate the immunosuppressive tumor microenvironment.
- Preclinical data show efficacy, but context-dependent toxicities such as liver fibrosis risk may limit therapeutic windows.
- Clinical translation requires biomarker-guided trials, nanoformulation optimization, metabolic imaging, and safety monitoring for metabolic plasticity.