The Impact of Endometriosis on Ovarian Reserve: A Systematic Review - PubMed
4 hours ago
- #fertility
- #ovarian reserve
- #endometriosis
- Endometriosis is a chronic inflammatory condition that negatively affects ovarian reserve, particularly in cases with ovarian endometriomas.
- The systematic review, following PRISMA guidelines, included 10 studies from 2015-2024 and found endometriosis significantly reduces ovarian reserve, indicated by lower AMH levels and AFC.
- Endometriosis is linked to chronic pelvic inflammation and oxidative stress, disrupting ovarian function and damaging oocytes.
- Surgical interventions like cystectomy can manage symptoms but may risk further reducing ovarian reserve by removing healthy tissue.
- Early diagnosis and personalized management are crucial to preserve ovarian function and fertility.
- Future research should focus on developing treatments considering immune and hormonal influences, exploring methods to protect/regenerate ovarian reserve, and analyzing endometriosis subtypes.