Suppression of LncRNA AC008406.3 sensitizes breast cancer cells to docetaxel via triggering cuproptosis - PubMed
3 hours ago
- #docetaxel resistance
- #cuproptosis
- #breast cancer
- The study identifies lncRNA AC008406.3 as a cuproptosis-related prognostic factor in breast cancer, with high expression linked to poor outcomes.
- Knockdown of AC008406.3 induces cuproptosis in breast cancer cells by increasing copper levels and reducing lipoylated and Fe-S cluster proteins, inhibiting cell proliferation and invasion.
- Docetaxel (DTX) induces cuproptosis in breast cancer, but AC008406.3 suppresses this process, reducing DTX sensitivity; AC008406.3 knockdown enhances DTX's anti-tumor efficacy.
- Targeting AC008406.3 may sensitize breast cancer cells to DTX chemotherapy by promoting cuproptosis.