Epithelial cells fire voltage spikes - PubMed
3 hours ago
- #Epithelial Excitability
- #Bioelectricity
- #Mechanosensitive Channels
- Epithelial cells exhibit voltage spikes after localized injury, demonstrating bioelectric excitability.
- Spikes occur over extended periods and have slow phases, unlike neuronal action potentials.
- Calcium influx and actomyosin contractility are required for spike generation.
- Mechanosensitive channels, including TRPV4 and Piezo1, are key drivers of this electrical activity.
- Activation of these channels can induce spikes even without injury, indicating their sufficiency.