cGAS-STING pathway regulated by spatiotemporal heterogeneity of tumor microenvironment and precision therapy strategies in lung cancer - PubMed
2 days ago
- #tumor microenvironment
- #cGAS-STING pathway
- #lung cancer
- The cGAS-STING pathway has dual roles in lung cancer, both promoting anti-tumor immunity and enabling immune escape or metastasis, influenced by TME spatiotemporal heterogeneity.
- Spatiotemporal heterogeneity in the TME involves dynamic changes in immune and metabolic features across regions and disease stages, modulating cGAS-STING activity via cell interactions and physicochemical gradients.
- Precision immunotherapy strategies targeting the cGAS-STING pathway, along with AI optimization, aim to overcome therapy resistance and improve patient outcomes in lung cancer.