Multimodal transcriptomics reveal myCAF-derived collagen signaling associated with impaired NK-cell cytotoxicity and immune exclusion in pancreatic cancer - PubMed
3 hours ago
- #Pancreatic cancer
- #NK cell dysfunction
- #Immunotherapy resistance
- Multimodal transcriptomics study links myofibroblastic cancer-associated fibroblasts (myCAFs) to impaired natural killer (NK) cell function in pancreatic ductal adenocarcinoma (PDAC).
- Identified a tumor-associated NK (TaNK) subset with reduced cytotoxicity, primarily influenced by myCAF-derived collagen signaling.
- Key ligand-receptor pairs COL1A2-CD44 and COL1A1-LAIR1 were found to mediate stromal remodeling and NK cell impairment.
- Spatial and histological analyses confirmed co-localization of myCAFs and TaNKs, associated with immune exclusion and poor immunotherapy response.
- Targeting the myCAF-NK axis is suggested as a potential strategy to enhance immunotherapy efficacy in PDAC.