Visceral adipose tissue differentially affects tau and Aβ pathology in 3xTg-AD mice - PubMed
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- #Alzheimer's disease
- #Neuroinflammation
- #Metabolic disorders
- Study investigates the role of visceral white adipose tissue (WAT) in Alzheimer's disease (AD) using 3xTg-AD mice, showing differential effects on tau and Aβ pathology.
- Transplantation of WAT from db/db mice (modeling metabolic dysfunction) into 3xTg-AD mice increased tau pathology via enhanced p25/cdk5 expression and inflammation, but reduced Aβ levels due to improved microglial phagocytosis.
- Findings suggest a novel crosstalk between metabolic disorders and AD mediated by adipose tissue signaling and immune responses, highlighting obesity and diabetes as AD risk factors.