A bone-marrow-homing biomimetic STING nanoinhibitor alleviates radiation-induced hematopoietic injury via modulating macrophage polarization - PubMed
3 hours ago
- #Radiation injury
- #Biomimetic nanocarriers
- #Macrophage polarization
- Development of a bone-marrow-homing STING nanoinhibitor using senescent neutrophil membrane coating for targeted delivery.
- The nanoinhibitor suppresses cGAS-STING signaling to shift macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotype, reducing inflammation and ROS accumulation.
- In mouse models, it alleviates radiation-induced pancytopenia, preserves bone marrow structure, accelerates recovery, and avoids significant side effects.