ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation - PubMed
3 hours ago
- #Inflammation
- #DNA repair
- #Cellular senescence
- ZNF512B is identified as a key suppressor of the senescence-associated secretory phenotype (SASP) through a CRISPR-Cas9 screen.
- Loss of ZNF512B leads to DNA damage, activates cGAS-STING signaling, and triggers inflammatory reprogramming, whereas ZNF512B promotes DNA repair at regulatory regions to limit SASP.
- ZNF512B is recruited to DNA-damage sites and facilitates NuRD complex targeting for precise repair, with deficiency in human neuromuscular organoids mimicking ALS-like inflammation and imbalance.
- In vivo, ZNF512B overexpression reduces DNA damage and inflammation after acute liver injury, supporting a role in maintaining genome integrity and suppressing inflammation.