Nanomaterials targeting cancer-associated fibroblasts to overcome stromal barriers in cancer immunotherapy - PubMed
3 hours ago
- #Nanomaterials
- #CAFs
- #Cancer Immunotherapy
- Cancer-associated fibroblasts (CAFs) are key players in the tumor microenvironment, affecting tumor progression, immune evasion, metastasis, and therapy resistance.
- Targeting CAFs through nanotechnology offers promising strategies to modulate the tumor microenvironment and enhance cancer immunotherapy efficacy.
- Key strategies include CAF reprogramming, disruption of ECM barriers, and targeting immune checkpoints to create a more immune-permissive environment.
- Challenges remain in optimizing nanoparticle delivery, overcoming CAF-related drug resistance, and addressing complex immunosuppressive networks.
- Future research should focus on developing targeted, personalized nanomedicine approaches and improving CAF-specific drug delivery systems.