The Prognostic Value of Serum Inflammatory Markers in Nasopharyngeal Carcinoma Patients Treated With Immune Checkpoint Inhibitors: A Multicenter Study - PubMed
2 hours ago
- #survival analysis
- #biomarkers
- #immunotherapy
- This multicenter study investigated serum inflammatory markers as prognostic predictors for nasopharyngeal carcinoma (NPC) patients treated with immune checkpoint inhibitors (ICIs).
- The analysis included 170 patients in the training cohort and identified hemoglobin (Hb), Prognostic Nutritional Index (PNI), and number of metastases as independent prognostic factors for overall survival (OS).
- A nomogram based on these three factors showed good predictive performance with a C-index of 0.733 in training and 0.743 in validation cohorts.
- Time-dependent ROC curves for 1-, 2-, and 3-year OS demonstrated favorable accuracy, and decision curve analysis supported the model's clinical utility.
- The study concludes that combining serum inflammatory markers with clinicopathological factors can serve as a practical prognostic tool to identify NPC patients likely to benefit from ICI treatment.