Global burden, projections, and causal factors of maternal sepsis and other maternal infections: A comprehensive epidemiological and mendelian randomization study - PubMed
2 hours ago
- #maternal infections
- #causal inference
- #global burden
- Global maternal sepsis and other maternal infections (MSMI) contribute significantly to maternal morbidity and mortality worldwide.
- From 1990 to 2021, age-standardized rates of MSMI declined globally, but absolute case numbers increased in low-SDI regions due to population growth.
- Future projections using ARIMA and Bayesian age-period-cohort models showed differing results, reflecting variations in temporal assumptions.
- Multivariable Mendelian randomization identified inflammatory biomarkers (CRP, IL-13, IL-10, RANTES, NT-proBNP) as key causal factors for MSMI.
- The study integrates epidemiological trends with causal inference to support targeted prevention and precision public health strategies for MSMI.