Long-term ovarian function risks associated with combined oral contraceptive administration in polycystic ovary syndrome: multisource data integration and protective mechanisms of metformin - PubMed
3 hours ago
- #PCOS
- #Oral Contraceptives
- #Ovarian Function
- Prolonged use of combined oral contraceptives (COCs) in PCOS patients is linked to higher risks of premature ovarian insufficiency and failure.
- Metformin use may reduce the risk of ovarian function decline in these patients, suggesting a protective effect.
- The study integrates clinical data, pharmacovigilance reports, and computational analysis to explore COC-related ovarian toxicity mechanisms.
- Computational findings indicate metformin might mitigate risks through competitive binding and pathway modulation.