Glucagon-Like Peptide-1 Receptor Agonist and Hyponatremia: A Potential Association - PubMed
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- #hyponatremia
- #GLP-1 agonist
- #tirzepatide
- GLP-1 receptor agonists are widely used for diabetes and obesity, but side effects beyond gastrointestinal issues are not fully understood.
- A case of a 73-year-old woman on chlorthalidone developed hyponatremia after starting tirzepatide, with sodium levels fluctuating with dose changes and normalizing after discontinuation.
- The case suggests a temporal link between tirzepatide and hyponatremia, possibly exacerbated by concurrent thiazide-like diuretic use.
- Clinicians should monitor serum sodium in patients on GLP-1 receptor agonists, especially with co-administered sodium-affecting drugs like thiazide diuretics.