Long-term outdoor air pollution and risk of ovarian and endometrial cancers in a large prospective cohort - PubMed
3 hours ago
- #cohort study
- #gynecologic cancers
- #air pollution
- Long-term outdoor air pollution (PM2.5 and NO2) was evaluated for associations with ovarian and endometrial cancers in a large prospective cohort study.
- No overall relationships were found between air pollutants and risk of either cancer.
- PM2.5 was associated with increased endometrial cancer risk in specific geographic areas (Atlanta, Georgia and Pennsylvania).
- Suggestive associations were observed for ovarian cancer in Detroit, Michigan, though estimates were imprecise.
- NO2 showed positive associations with non-endometrioid endometrial cancers, and PM2.5 with non-epithelial ovarian tumors.
- Associations varied by neighborhood deprivation levels, with stronger links in more deprived areas.
- Relationships did not vary by body mass index (BMI).
- The study highlights the importance of region-specific factors and pollutant mixtures in cancer development.