Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells - PubMed
3 hours ago
- #Oncogenic Transformation
- #Mechanotransduction
- #Cell Competition
- Filamin-ETV4/5 acts as a mechanosensor-mechanotransducer axis driving cell competition-mediated elimination of transformed cells.
- Transformed cells increase in volume, stretching membranes, which adjacent normal cells sense via filamin, activating ETV4/5.
- Activated ETV4/5 upregulate PRKG2, promoting volume expansion in normal cells, which pushes back and extrudes transformed cells.
- This reveals that cell volume changes trigger mechanotransduction-driven cell competition, helping epithelial tissues maintain homeostasis and defend against oncogenic transformation.