Evening circadian preference as a potential risk factor for cancer-depression comorbidity: a comprehensive analysis from population cohort to molecular insights - PubMed
3 hours ago
- #cancer-depression-comorbidity
- #evening-chronotype
- #neuro-endocrine-immune-dysregulation
- Evening chronotype increases risk of cancer-depression comorbidity, especially for breast and colorectal cancers.
- High-risk subgroups include females, smokers, and lower-income individuals, identified from UK Biobank cohort.
- Genetic analyses link evening chronotype with higher comorbidity risk, supported by Mendelian randomization and polygenic risk scores.
- Key circadian clock-related genes (GAL, ALAS1, SUCNR1, PTK2, DDIT3) show shared pathways for cancer and depression.
- Neuro-endocrine-immune dysregulation, via mast cell and CD8+ T cell infiltration, is suggested as a pathway from circadian disruption to comorbidity.