Roquefortine C Isolated from a Quail Feces-Derived Fungus Exhibits Aryl Hydrocarbon Receptor Antagonistic and Broad-Spectrum Antiviral Activities - PubMed
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- #Antiviral Activity
- #Fungal Metabolites
- #Aryl Hydrocarbon Receptor
- Roquefortine C, isolated from a quail feces-derived fungus, acts as an aryl hydrocarbon receptor (AhR) antagonist.
- AhR inhibition reduces lipid droplet accumulation and suppresses hepatitis C virus (HCV) proliferation.
- Roquefortine C exhibits broad-spectrum antiviral activity against HCV, herpes simplex virus type 1 (HSV-1), and pseudorabies virus (PRV).
- The study demonstrates a novel relationship between AhR and PRV, suggesting AhR ligands as potential broad-spectrum antiviral compounds.