NLRP3 haploinsufficiency unmasks a compensatory NLRP1-NLRP3 interaction that drives accelerated aging in mice - PubMed
3 hours ago
- #inflammatory compensation
- #accelerated aging
- #NLRP3 inflammasome
- NLRP3 haploinsufficiency leads to accelerated inflammatory aging in mice, with symptoms appearing by 16 months of age.
- The effect is driven by compensatory overexpression of NLRP1, which interacts with NLRP3 to form a hybrid inflammasome.
- Anti-inflammatory treatment provides moderate improvement, while genetic inhibition of Nlrp1 more effectively reduces inflammation and extends health span.
- Findings suggest multi-inflammasome inhibition may be a more effective strategy for treating aging and age-related diseases.