FN1+ macrophages fuel aggressive sarcomatoid differentiation and immunotherapy refractory outcome in clear cell renal cell carcinoma - PubMed
4 hours ago
- #sarcomatoid differentiation
- #ccRCC immunotherapy
- #FN1+ macrophages
- FN1+ tumor-associated macrophages (TAMs) are enriched in clear cell renal cell carcinoma (ccRCC) with sarcomatoid differentiation and correlate with epithelial-mesenchymal transition (EMT) signatures.
- High infiltration of FN1+ TAMs is associated with immunotherapy resistance, CD8+ T cell dysfunction, and inferior survival outcomes in ccRCC patients.
- FN1 blockade reverses EMT-associated programs, reduces immunosuppressive molecules in macrophages, and restores CD8+ T cell effector function.
- Combination therapy targeting FN1 and PD-1 synergistically enhances T cell cytotoxicity and tumor cell apoptosis, offering a potential therapeutic strategy.