Lactobacillus-derived indole-3-lactic acid suppresses meningioma malignant phenotypes by direct anti-proliferative effects and macrophage reprogramming - PubMed
3 days ago
- #Intratumoral Microbiome
- #Indole-3-Lactic Acid
- #Meningioma
- The study characterized the intratumoral microbiome of meningiomas, finding distinct microbial communities between benign and non-benign tumors.
- Lactobacillus was enriched in benign tumors and negatively correlated with the Ki-67 proliferation index, suggesting it as a potential microbial marker for less aggressive tumors.
- Functional analysis showed that Lactobacillus intestinalis supernatant suppressed meningioma cell proliferation and migration.
- Indole-3-lactic acid (ILA) was identified as a key metabolite from Lactobacillus, with direct anti-proliferative effects on tumor cells and the ability to reprogram macrophages toward an M1 phenotype.
- ILA demonstrated dual anti-tumor activity through direct effects and immunomodulation, positioning it as a potential preclinical candidate for therapeutic development.
- The findings are preliminary and require further in vivo validation to confirm the therapeutic potential of ILA in meningioma treatment.