CHI3L1 (YKL-40) and Chit-1 expressing glia in the white matter of ALS, FTLD and AD: correlations to pathology and disease duration - PubMed
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- #TDP-43 pathology
- #Chit-1
- #CHI3L1
- CHI3L1 (YKL-40) and Chit-1 levels are increased in the CSF of ALS, FTD, and AD.
- Chit-1 gene expression is elevated in the spinal cord, while CHI3L1 is increased in both spinal cord and motor cortex of ALS patients.
- Chit-1+ glia are highest in cortical regions with hallmark neuropathology across diseases.
- CHI3L1+ glia are significantly increased only in sporadic ALS (sALS).
- Chit-1+ and CHI3L1+ glia are not in close proximity to pTDP-containing neurons in grey matter, but co-localize with glial pTDP in white matter.
- Expressing cells are most abundant in white matter of affected cortical regions and spinal cord.
- White matter Chit-1 or CHI3L1 expressing cells often contain phosphorylated TDP-43 (pTDP).
- Levels of these expressing cells in white matter correlate with disease duration.