The evolving landscape of regulatory T cells in leukemia: from mechanisms to advanced immunotherapeutic strategies - PubMed
4 hours ago
- #Tregs
- #Immune Evasion
- #Leukemia Immunotherapy
- Regulatory T cells (Tregs) are key immunosuppressive cells in the leukemia tumor microenvironment, aiding immune evasion.
- Tregs play roles in various leukemias including AML, ALL, CML, and CLL, with mechanisms like CCL22/CCR4 axis, CD39/CD73 adenosine pathway, and IDO-mediated tryptophan catabolism.
- The prognostic impact of Treg infiltration varies across leukemia subtypes and is often discordant.
- Therapeutic strategies targeting Tregs include depleting antibodies (e.g., mogamulizumab), immunomodulatory small molecules (e.g., venetoclax), and overcoming challenges in cellular therapies.
- Novel approaches aim to circumvent Treg-mediated resistance to restore anti-leukemic immunity.