Peripapillary Retinal Nerve Fibre and Ganglion Cell Layer Changes Following Intravitreal Aflibercept 8 mg Therapy in Neovascular Age-Related Macular Degeneration: A Longitudinal OCT Study - PubMed
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- #longitudinal OCT study
- #anti-VEGF therapy
- #retinal neuroprotection
- The study investigates potential neuro-retinal structural safety of intravitreal aflibercept 8 mg therapy in neovascular age-related macular degeneration (nAMD) patients, focusing on changes in the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIP) over 12 months.
- A longitudinal cohort design was used, comparing eyes treated with aflibercept 8 mg to those treated with aflibercept 2 mg and fellow untreated eyes, utilizing spectral-domain optical coherence tomography for thickness measurements at baseline, 3, 6, and 12 months.
- Results indicate no significant thinning in mGCIP or pRNFL thickness in the aflibercept 8 mg group over 12 months, with no differences compared to other groups, suggesting that higher-dose aflibercept does not adversely affect these inner retinal structures in clinical practice.