Triglyceride-Glucose-Waist-to-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People With Sarcopenic Obesity - PubMed

2 hours ago

Sarcopenic obesity (SO) is strongly linked to mild cognitive impairment (MCI) in older adults.
Traditional SO criteria overlook insulin resistance, a key factor in MCI development.
The study uses data from three cohorts: Chongming Screening Project (2025), CHARLS, and ELSA.
A metabolically oriented SO definition combining sarcopenia with elevated TyG-WWI index shows consistent association with MCI across all cohorts.
TyG-WWI is identified as the optimal obesity indicator for MCI detection, with an AUC of 0.71.
An XGBoost model incorporating TyG-WWI achieves high discriminative performance for MCI risk in both cross-sectional and external validation studies.
Subgroup analyses indicate SO is particularly associated with declines in executive function and memory.
The findings suggest that metabolic-focused SO criteria are more effective than traditional body composition-based ones for identifying MCI in older community-dwelling individuals.

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