Integrating Multi-Source Biomedical Data for Adverse Drug Reaction Analysis: A Knowledge Graph Approach - PubMed
3 hours ago
- #Adverse Drug Reactions
- #Data Integration
- #Knowledge Graphs
- A pipeline integrates drug-target data (DrugBank), biochemical pathways (Reactome), and adverse drug reactions (SIDER) into RDF/OWL knowledge graphs for analyzing adverse drug reaction mechanisms.
- The approach extracts protein targets from DrugBank, biochemical reactions from Reactome, and top adverse reactions from SIDER, linking them in a unified graph.
- Applied to metformin as a proof-of-concept, the graph contains 139 triples connecting 1 drug, 3 protein targets, 2 reactions, 2 pathways, and 5 adverse reactions, demonstrating technical feasibility.
- Future steps focus on automating the integration process to enhance scalability and efficiency.