Multimodal clocks of human aging - PubMed
2 days ago
- #biomarkers
- #aging clocks
- #coagulation factors
- Study presents multimodal clocks of human aging using a cohort of 2,019 Chinese individuals aged 18-91 years.
- Developed a three-tiered aging framework: core capacity clock (CC-clock), multimodal clock (MM-clock), and organ-associated clocks.
- Plasma protein clocks capture chronological age and serve as proxies for systemic physiological capacity.
- Identified age-dependent accumulation of coagulation factors as a driver of multi-organ senescence and systemic inflammatory activation.
- Provides a foundational framework linking molecular signatures to functional decline, offering new biomarkers and revealing novel aging drivers.